Acanthosis nigricans
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Hè cumuni in e persone obese.
relevance score : -100.0%
ReferencesAcanthosis nigricans hè una manifestazione cutanea di una cundizione sottostante. Spessu apparisce in i piegamenti di a pelle cum'è u collu, l'ascelle è l'inguine, cum'è macchie scure vellutate cù bordi pocu chjaru. Sta cundizione hè generalmente ligata à a diabete è à a resistenza à l'insulina, ma in casi rari puderia indicà u cancro in u corpu. Puderia ancu esse per via di prublemi ormonali o per via di l'assunzione di medicazione specifica, cum'è steroidi è pilule di cuntrollu di natalità.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) hè una cundizione cumuna di a pelle ligata à diversi prublemi di salute cum'è a resistenza à l'insulina, a diabete, l'obesità, certi cancri, i prublemi hormonali è e reazzioni à i medicamenti. U trattamentu di l'AN si concentra nantu à affruntà i prublemi di salute sottostanti. In principiu, i medichi trattanu i segni di u sindromu di resistenza à l'insulina, chì include l'obesità, u colesterolu altu, a pressione di u sangue è a diabetes mellitus 2. I medichi spessu prescrivenu retinoidi topichi cum'è prima scelta di trattamentu, chì ponu aiutà à l'engrossamentu di a pelle. Tuttavia, ùn ponu micca affruntà cumpletamente l'oscurità di a pelle. Altre opzioni di trattamentu (salicylic acid, podophyllin, urea, calcipotriol) richiedenu ancu una applicazione frequente.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ Causes
Si manifesta tipicamente in individui più ghjovani di 40 anni, pò esse ereditatu geneticamente è hè associatu à l’obesità o à l’endocrinopatie, cum’è l’ipotiroïdismu, l’acromegalia, a sindrome di l’ovaio policisticu, a diabetes resistente à l’insulina o a malatia di Cushing.
○ Trattamentu - Drugs OTC
#40% urea cream